Patient Support Programs Trends 2026 SURVEY REPORT PSP Trends-desktop small 1440x360 PSP Trends-mobile 428x332 PSP Trends-tablet 1024x920 As patient access, affordability, and regulatory challenges intensify, patient support programs are being forced to evolve. Guidehouse’s 2026 Patient Support Programs (PSP) Trends examine how biopharma manufacturers are adapting PSP strategies to meet fast-changing patient, payer, and policy demands. Based on a survey of pharmaceutical executives, the report highlights how organizations are rethinking operational models, shifting service offerings, and leveraging technology to improve access and support business priorities. Our report explores: Key trends and priorities shaping patient support programs The most-used services and the challenges manufacturers face in implementing them How AI, insourcing, and reimbursement complexity are impacting the PSP landscape 2026 psp trends - 40 are using both external and internal HUB services 40% 2026 psp trends - 14 feel "very prepared" to adapt to the Inflation Reduction Act 14% 2026 psp trends - 80 say copay assistance programs are the most-used PSP 80% Report insights biggest challenges-1 Leaders cite affordability pressures, payer dynamics such as copay accumulator and maximizer programs, reimbursement and prior authorization delays, and data integration and governance challenges as top obstacles. What are the biggest challenges facing patient support programs today? Whats changing-2 Organizations are adopting more technology enabled, hybrid operating models, bringing some services in house while relying on partners for scale, speed, and advanced capabilities such as AI. How are patient support programs changing? Role AI plays-3 AI is being used to automate reimbursement workflows, improve data visibility, and generate insights that help reduce delays and improve patient and provider experiences—though adoption and maturity vary widely. What role does AI play in patient support programs? Regulations-4 Policy changes such as the Inflation Reduction Act, PBM reform, and evolving CMS rules are prompting manufacturers to reassess affordability programs, eligibility criteria, and overall PSP design. How are regulations affecting patient support strategies? Actions-5 The report outlines practical actions, including rebalancing investments upstream, adopting hybrid operating models, embedding payer strategy into PSP design, and tying program performance to measurable outcomes. What actions can PSP leaders take now? About the report